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RESEARCH PRODUCT
Genetically Determined Height and Risk of Non-hodgkin Lymphoma
Amy MooreEleanor KaneZhaoming WangZhaoming WangOrestis A. PanagiotouOrestis A. PanagiotouLauren R. TerasAlain MonnereauAlain MonnereauAlain MonnereauNicole Wong DooMitchell J. MachielaChristine F. SkibolaSusan L. SlagerGilles SallesGilles SallesGilles SallesNicola J. CampPaige M. BracciAlexandra NietersRoel C. H. VermeulenRoel C. H. VermeulenJoseph VijaiKarin E. SmedbyKarin E. SmedbyYawei ZhangClaire M. VajdicWendy CozenWendy CozenJohn J. SpinelliJohn J. SpinelliHenrik HjalgrimGraham G. GilesGraham G. GilesBrian K. LinkJacqueline ClavelJacqueline ClavelAlan A. ArslanAlan A. ArslanAlan A. ArslanMark P. PurdueLesley F. TinkerDemetrius AlbanesGiovanni Maria FerriThomas M. HabermannHans-olov AdamiHans-olov AdamiNikolaus BeckerYolanda BenaventeYolanda BenaventeSimonetta BisanziPaolo BoffettaPaul BrennanAngela R. Brooks-wilsonAngela R. Brooks-wilsonFederico CanzianLucia CondeDavid G. CoxKaren CurtinLenka ForetovaSusan M. GapsturHervé GhesquièresHervé GhesquièresMartha GlennBengt GlimeliusRebecca D. JacksonQing LanMark LiebowMarc MaynadieJames MckayMads MelbyeMads MelbyeLucia MiligiRoger L. MilneRoger L. MilneThierry Jo MolinaLindsay M. MortonKari E. NorthKari E. NorthKenneth OffitMarina PadoanAlpa V. PatelSara PiroVignesh RavichandranElio RiboliSilvia De SanjoseSilvia De SanjoseRichard K. SeversonMelissa C. SoutheyAnthony StainesCarolyn StewartRuth C. TravisElisabete WeiderpassStephanie WeinsteinTongzhang ZhengStephen J. ChanockNilanjan ChatterjeeNilanjan ChatterjeeNilanjan ChatterjeeNathaniel RothmanBrenda M. BirmannJames R. CerhanSonja I. Berndtsubject
0301 basic medicineOncologyCancer Researchmedicine.medical_specialtyChronic lymphocytic leukemiaFollicular lymphomadiffuse large B-cell lymphomaSingle-nucleotide polymorphismGenome-wide association studylcsh:RC254-28203 medical and health sciences0302 clinical medicinefollicular lymphomaimmune system diseasesInternal medicinehemic and lymphatic diseasesGeneticsMedicineLeucèmia limfocítica crònicageneticsOriginal ResearchGenetic associationCancer och onkologibusiness.industrynon-Hodgkin lymphomaOdds ratiomedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmarginal zone lymphomaLymphomaMalaltia de Hodgkin030104 developmental biologyOncologyCancer and Oncology030220 oncology & carcinogenesispolygenic risk scorediffuse large B-celllymphomachronic lymphocytic leukemiaChronic lymphocytic leukemiaHodgkin's diseasegeneticbusinessDiffuse large B-cell lymphomaGenèticaheightdescription
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-28 | Frontiers in Oncology |