6533b856fe1ef96bd12b2894
RESEARCH PRODUCT
Natural beta-interferon and androgen receptors in prostatic cancer cells.
M. CacciatoreFortunata IacopinoMichele Pavone-macalusoL. FabbroniPiero MarchettiGigliola SicaG. Dell’acquasubject
Malemedicine.medical_specialtymedicine.drug_classUrologymedicine.medical_treatmenturologic and male genital diseasesCell LineProstateInternal medicinemedicineTumor Cells CulturedHumansβ interferonbusiness.industryProstatic NeoplasmsImmunotherapyAndrogenAndrogen receptorEndocrinologymedicine.anatomical_structureCell cultureReceptors AndrogenCancer cellInterferon Type IbusinessInterferon type Imedicine.drugdescription
Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural beta-interferon at a concentration of 1,000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-01-01 | Urologia internationalis |