6533b856fe1ef96bd12b2f68

RESEARCH PRODUCT

Design of guanidinium porphyrins as potential G-quadruplex ligands

Claude P. GrosHai-jun XuPhilippe RichardJean-michel Barbe

subject

chemistry.chemical_compoundchemistryStereochemistryLigandPhthalocyanineMoleculeGeneral ChemistryG-quadruplexPorphyrinGuanidine derivatives

description

We report herein an easy and smooth synthesis of two novel tetra-meso-substituted porphyrins bearing terminal guanidinium functionalities. These two guanidine derivatives are the porphyrin-based analogs of ZnPC , a closely related phthalocyanine-based molecule with four guanidinium arms already reported as an efficient G-quadruplex ligand.

https://doi.org/10.1142/s108842461250109x