6533b856fe1ef96bd12b2ff8
RESEARCH PRODUCT
New imaging procedures in thyroid-associated ophthalmopathy
George J. Kahalysubject
medicine.diagnostic_testSomatostatin receptorbusiness.industryOctreotide scanOctreotideMagnetic resonance imagingImaging ProceduresExtraocular musclesPeripheral blood mononuclear cellOphthalmologymedicine.anatomical_structuremedicinesense organsNuclear medicinebusinessThyroid-Associated Ophthalmopathymedicine.drugdescription
Lymphocytic and other mononuclear cell infiltrations of the retrobulbar space are observed in thyroid-associated ophthalmopathy (TAO). The identification of somatostatin receptors on lymphocytes has provided a rationale for receptor-imaging with the radiolabeled somatostatin analog Octreotide in TAO. Furthermore, previous investigations have shown that quantitative magnetic resonance imaging (MRI) allows non-invasive detection of acute inflammatory changes in extraocular muscles. Therefore, in patients with TAO and controls, scans of the orbits were obtained at 4h and 24h after i.v. injection of the radionuclide and orbital MRI was performed. Compared to controls, patients with TAO showed a three-fold increased uptake (p = 0.0032). When considering patients with active disease only, an even higher uptake was observed (vs controls p = 0.0006). MRI revealed markedly increased values of T2 relaxation time in extraocular muscles of untreated patients with active disease as well as a positive correlation betwe...
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-01-01 | Orbit |