6533b856fe1ef96bd12b32e2
RESEARCH PRODUCT
Malignancy course of pituitary adenoma in MEN1 syndrome: Clinical-Neuroradiological signs
Giuseppe SalvaggioCesare GagliardoPaola FeracoValeria PutortìGiovanni LasioCaterina SarnoGiuseppe La TonaFrancesca IncandelaLaura Geracisubject
lcsh:Medical physics. Medical radiology. Nuclear medicinePathologymedicine.medical_specialtymedicine.medical_treatmentlcsh:R895-920Neoplasm metastasisTentorium cerebelliPituitary neoplasmPituitary neoplasmsMalignancyArticle030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicinePituitary adenomamedicineEndocrine systemRadiology Nuclear Medicine and imagingMEN1Ki-67 antigenNeoplasm metastasiPituitary carcinomabusiness.industryMagnetic resonance imaging MRISettore MED/37 - Neuroradiologiamedicine.diseasePituitary adenomaRadiation therapy030220 oncology & carcinogenesisPituitary neoplasms Pituitary carcinoma Pituitary adenoma Neoplasm metastasis Ki-67 antigen Magnetic resonance imaging MRIPituitary carcinomaSettore MED/36 - Diagnostica Per Immagini E Radioterapiabusinessdescription
Pituitary carcinomas (PCa) are extremely rare, indistinguishable from pituitary adenomas on histopathological grounds and have a poor prognosis. Most PCa start as PRL or ACTH secreting tumors in males, with relapsing invasive behaviour, refractoriness to medical and radiotherapy and increasing hormonal levels. The presence of distant metastases is still required for the diagnosis of PCa. The association with genetic endocrine diseases must be taken into account, since it adds further risk of evolution towards malignancy. Intradural spinal metastases have also been reported, so a complete craniospinal MR evaluation is recommended, when clinically indicated. We report a case of PCa, associated with MEN1 syndrome, with evidence of meningeal spread to the tentorium cerebelli, clival dura and spinal drop metastases mimicking spinal nerves schwannomas.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-06-01 | European Journal of Radiology Open |