6533b857fe1ef96bd12b38d2

RESEARCH PRODUCT

Effects of Trimipramine on Sleep EEG, Penile Tumescence and Nocturnal Hormonal Secretion

A. SteigerS. WöhrmannFlorian HolsboerO. BenkertD. Steinseifer

subject

Cortisol secretionendocrine systemmedicine.medical_specialtyRapid eye movement sleepTrimipramineProlactinfilm.subjectPsychiatry and Mental healthNeuropsychology and Physiological PsychologyEndocrinologyfilmInternal medicineNocturnal penile tumescencePenile TumescencemedicinePsychologyhormones hormone substitutes and hormone antagonistsBiological PsychiatryTestosteroneHydrocortisonemedicine.drug

description

Sleep EEG, nocturnal penile tumescence (NPT) and nocturnal endocrine activity were studied in 3 male control subjects during placebo, under trimipramine (TR) and after withdrawal. TR did not change the sleep structure. NPT activity tended to increase under TR. Nocturnal plasma cortisol levels decreased markedly while the early morning rise of cortisol appeared delayed under 200 mg TR. After withdrawal the changes of the cortisol secretion rebounded. Nocturnal secretion of GH, testosterone, LH and FSH remained unaffected, but plasma prolactin levels increased under TR and returned to normalcy after cessation. Our data illustrate that the neurobiological effects of TR are different from those of other antidepressants. We suggest that some of the psychotropic effects of TR are mediated by suppression of cortisol.

yearjournalcountryeditionlanguage
1989-01-01Neuropsychobiology
https://doi.org/10.1159/000118555