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RESEARCH PRODUCT

A closer look at the cholesterol sensor

Falk FahrenholzKatja BurgerGerald Gimpl

subject

Conformational changeCholesterolEndoplasmic reticulumVesicleBiologyGolgi apparatusBiochemistrySterolSterol regulatory element-binding proteinCell biologysymbols.namesakechemistry.chemical_compoundBiochemistryStructural biologychemistrypolycyclic compoundssymbolslipids (amino acids peptides and proteins)Molecular Biology

description

Abstract Transport of the sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP)–SREBP complex from the endoplasmic reticulum (ER) to the Golgi is the central event mediating the cholesterol-feedback process in mammalian cells. A conformational change in SCAP is a crucial step; when cholesterol levels are high, the conformation of SCAP enables the SCAP–SREBP complex to associate with an insulin-induced gene (INSIG) retention protein in the ER. By contrast, when cholesterol levels are low, SCAP switches to a conformation that enables the dissociation of the retention protein and the association of SCAP–SREBP with COP II vesicles.

yearjournalcountryeditionlanguage
2002-12-01Trends in Biochemical Sciences
https://doi.org/10.1016/s0968-0004(02)02224-7