6533b857fe1ef96bd12b3b18
RESEARCH PRODUCT
B cells in the aged: CD27, CD5, and CD40 expression.
Giuseppe ScialabbaMassimo MottaCalogero CarusoGiuseppina Colonna-romanoCandoregiuseppinaAlessandra AquinoMatteo BulatiMariano MalaguarneraDomenico Liosubject
Adultmedicine.medical_specialtyAgingNaive B cellchemical and pharmacologic phenomenaCD5 AntigensNatural killer cellInterleukin 21immune system diseasesInternal medicinemedicineHumansLymphocyte CountCD154CD40 AntigensAntigen-presenting cellAgedAged 80 and overB-LymphocytesCD40biologyhemic and immune systemsMiddle AgedMolecular biologyTumor Necrosis Factor Receptor Superfamily Member 7B-1 cellmedicine.anatomical_structureEndocrinologybiology.proteinInterleukin 12BiomarkersDevelopmental Biologydescription
Ageing is characterized by numerous changes in lymphocyte subpopulations. In the present paper we have focused on B cells carrying the surface markers CD27, CD5 and CD40. CD27 is considered a marker of primed (memory) cells and its engagement promotes the differentiation of memory B cells into plasma cells. CD5 is expressed on B1 cells, which are considered to be responsible for T cell-independent antibody production other than autoantibodies. The CD40 molecule binds CD40L (CD154) and is necessary for T-dependent antibody responses. Here we show that the absolute number of CD5+ and CD40+ B cells is decreased in the elderly, while CD27+ B lymphocytes only marginally decrease in centenarians. However, there is a decrease of the percentage of CD5+ B cells, an increase of CD27+ B cells, while CD40 does not change significantly. These data, together with the increased number of NK cells during aging, suggest different regulation of antibody production in the elderly which might be another example of immune remodeling with aging, based on interactions between human B and NK cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-04-01 | Mechanisms of ageing and development |