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RESEARCH PRODUCT
Evolutionary impact of copy number variation rates.
Guillermo Rodrigosubject
0301 basic medicineGenome sizeDNA Copy Number VariationsGene duplicationPopulation geneticsPopulation geneticslcsh:MedicineBiologyGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesEffective population sizeGenetic driftGenetic variationAnimalsHumansCopy-number variationlcsh:Science (General)Genome sizelcsh:QH301-705.5GeneticsNatural selectionlcsh:RGenetic DriftBirth–death processGeneral MedicineBiological EvolutionResearch Note030104 developmental biologyGenetics Populationlcsh:Biology (General)Evolutionary biologyNeutral theory of molecular evolutionNeutral evolutionlcsh:Q1-390description
[Objective]: Copy number variation is now recognized as one of the major sources of genetic variation among individuals in natural populations of any species. However, the relevance of these unexpected observations goes beyond diagnosing high diversity. [Results]: Here, it is argued that the molecular rates of copy number variation, mainly the deletion rate upon variation, determine the evolutionary road of the genome regarding size. Genetic drift will govern this process only if the efective population size is lower than the inverse of the deletion rate. Otherwise, natural selection will do.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 | BMC research notes |