6533b857fe1ef96bd12b3c09

RESEARCH PRODUCT

Efficacy of progressive aquatic resistance training for tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis : a randomised controlled trial

Harri SelänneUrho M. KujalaMiika T. NieminenMiika T. NieminenMatti MunukkaEveliina LammentaustaBenjamin WallerSarianna SipiläTimo RantalainenIlkka KivirantaAri HeinonenJuha PalonevaArttu PeunaArttu PeunaArja HäkkinenHannu Kautiainen

subject

Cartilage ArticularAquatic exerciseKnee JointrustoIsometric exerciseOsteoarthritislaw.invention0302 clinical medicineRandomized controlled triallawmagnetic resonance imagingMedicineOrthopedics and Sports MedicineRandomised controlled trialJOINTmagneettikuvausta3141Osteoarthritis KneePostmenopausemedicine.anatomical_structureFemalemedicine.symptomBONEmedicine.medical_specialtyGADOLINIUM-ENHANCED MRIBiomedical Engineering03 medical and health sciencesRheumatologyOsteoarthritisTHICKNESSWater environmentHumansMagnetic resonance imaging (MRI)030203 arthritis & rheumatologyRUNNING EXERCISEbusiness.industryCartilageaquatic exerciseResistance TrainingCardiorespiratory fitness030229 sport sciencesARTICULAR-CARTILAGEmedicine.disease3126 Surgery anesthesiology intensive care radiologyConfidence intervalGLYCOSAMINOGLYCAN DISTRIBUTIONQUANTITATIVE MRIosteoarthritisKnee painCartilagePHYSICAL-ACTIVITYPhysical therapyPATELLAR CARTILAGEbusinessrandomised controlled trial

description

Objective: To study the efficacy of aquatic resistance training on biochemical composition of tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis (OA). Design: Eighty seven volunteer postmenopausal women, aged 60-68 years, with mild knee OA (Kellgren-Lawrence grades I/II and knee pain) were recruited and randomly assigned to an intervention (n = 43) and control (n = 44) group. The intervention group participated in 48 supervised aquatic resistance training sessions over 16 weeks while the control group maintained usual level of physical activity. The biochemical composition of the medial and lateral tibiofemoral cartilage was estimated using single-slice transverse relaxation time (T2) mapping and delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC index). Secondary outcomes were cardiorespiratory fitness, isometric knee extension and flexion force and knee injury and OA outcome (KOOS) questionnaire. Results: After 4-months aquatic training, there was a significant decrease in both T2 -1.2 ms (95% confidence interval (CI): -2.3 to -0.1, P = 0.021) and dGEMRIC index -23 ms (-43 to -3, P = 0.016) in the training group compared to controls in the full thickness posterior region of interest (ROI) of the medial femoral cartilage. Cardiorespiratory fitness significantly improved in the intervention group by 9.8% (P = 0.010). Conclusions: Our results suggest that, in postmenopausal women with mild knee OA, the integrity of the collagen-interstitial water environment (T2) of the tibiofemoral cartilage may be responsive to low shear and compressive forces during aquatic resistance training. More research is required to understand the exact nature of acute responses in dGEMRIC index to this type of loading. Further, aquatic resistance training improves cardiorespiratory fitness. (C) 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. Peer reviewed

yearjournalcountryeditionlanguage
2016-10-01
10.1016/j.joca.2016.05.007http://hdl.handle.net/10138/225972