ESAT-6 Peptide Recognition by Bovine CD8 + Lymphocytes of Naturally Infected Cows in Herds from Southern Italy

6533b857fe1ef96bd12b3c2b

RESEARCH PRODUCT

ESAT-6 Peptide Recognition by Bovine CD8 + Lymphocytes of Naturally Infected Cows in Herds from Southern Italy

Annalisa Barera Enrico Petrotta Alfredo Salerno H. M. Vordermeier Francesco Dieli Guido Sireci Nadia Caccamo Stefano Reale Marco Pio La Manna Santo Caracappa Pasquale Macaluso Fabrizio Vitale

subject

Microbiology (medical)Molecular Sequence Data Clinical Biochemistry Immunology Epitopes T-Lymphocyte Peptide CD8-Positive T-Lymphocytes TUBERCULOSIS DIAGNOSIS Lymphocyte Activation complex mixtures ANTIGENS Veterinary Immunology Epitope Microbiology Interferon-gamma Mice Bacterial Proteins Antigen medicine Animals Immunology and Allergy Interferon gamma Amino Acid Sequence MACROPHAGES Sicily Peptide sequence Cells Cultured MYCOBACTERIUM-BOVIS chemistry.chemical_classification Antigens Bacterial Mycobacterium bovis biology bacterial infections and mycoses biology.organism_classification Mycobacterium bovis Virology chemistry ESAT-6 VACCINATION Cattle Female Tuberculosis Bovine CD8 medicine.drug

description

ABSTRACT The aim of this study was to define epitopes of Mycobacterium bovis from ESAT-6 (early secretory antigen of 6 kDa) recognized by CD8 + T lymphocytes from cows naturally infected with Mycobacterium bovis . We found that bovine CD8 + T cells recognized 10 out of 11 ESAT-6 peptides tested.

year	journal	country	edition	language
2006-04-01	Clinical and Vaccine Immunology

https://doi.org/10.1128/cvi.13.4.530-533.2006

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