6533b857fe1ef96bd12b3c2f
RESEARCH PRODUCT
Complement component deficiencies and infection: C5, C8 and C3 deficiencies in three families.
Gülten SeçmeerIlhan TezcanFügen ErsoyMichael LoosOzden SanalGüler Kanrasubject
MalePediatricsmedicine.medical_specialtyComplement Hemolytic Activity AssayMeningitis BacterialRecurrenceImmunopathologyRecurrent meningitisMedicineHumansSiblingChildRespiratory Tract Infectionsbusiness.industryMeningitis PneumococcalComplement C5Complement C3C5 Deficiencymedicine.diseaseComplement C8PedigreePneumoniaOtitisChild PreschoolPediatrics Perinatology and Child HealthImmunologyFemalemedicine.symptomComplicationbusinessMeningitisdescription
Three families are described with complement component deficiencies. In one family, five children had C5 deficiency; in a second family, two children had C8 deficiency and one child in a third family had C3 deficiency. The index cases were identified during screening of patients with recurrent pyogenic infections, recurrent meningitis and meningococcaemia. Two of the five C5 deficient patients had recurrent meningitis and meningococcaemia, two had recurrent respiratory tract infections and otitis and one was healthy. One of the C8 deficient patients had meningitis, meningococcaemia and pneumonia, whereas his sibling with the same deficiency was healthy. The patient with C3 deficiency had four episodes of meningitis and recurrent otitis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-09-01 | European journal of pediatrics |