Catalytic Enantioselective α-Oxysulfonylation of Ketones Mediated by Iodoarenes

6533b857fe1ef96bd12b43af

RESEARCH PRODUCT

Catalytic Enantioselective α-Oxysulfonylation of Ketones Mediated by Iodoarenes

Thomas Wirth Bernhard Witulski Bernhard Witulski Edward James Holland Umal Mohammed Shauna M. Paradine Shauna M. Paradine Christine Richter Christine Richter Robert D. Richardson Sabine Altermann Ruth K. Schmidt Ruth K. Schmidt A. Masih Bahar A. Masih Bahar T. Keri Page Andrew N. French Andrew N. French

subject

Chemistry Organocatalysis Reagent Yield (chemistry)Organic Chemistry Enantioselective synthesis Hypervalent molecule Organic chemistry Physical and Theoretical Chemistry Redox Stoichiometry Catalysis

description

The alpha-oxysulfonylation of ketones catalysed by enantioenriched iodoarenes using mCPBA as stoichiometric oxidant is reported to give useful synthetic intermediates in good yield and modest enantioselectivity. We believe this to be the first report of an enantioselective organocatalytic reaction involving hypervalent iodine reagents which should open up a new field for enantioselective organocatalysis of oxidation reactions.

year	journal	country	edition	language
2008-11-01	European Journal of Organic Chemistry

https://doi.org/10.1002/ejoc.200800741

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