6533b857fe1ef96bd12b44a2

RESEARCH PRODUCT

MOESM2 of Subtracting the sequence bias from partially digested MNase-seq data reveals a general contribution of TFIIS to nucleosome positioning

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Additional file 2. Metagene analysis of the chromatin and naked DNA signals. A, B) Genes were scaled to the same length and then aligned to their TSS or their pAS. All the genes in the yeast genome for which a TSS was available were considered. Zoom-in view of the data in Fig. 1a: A) closer to the TSS; B) closer to the pAS. C) Those genes whose pAS was at least 500 bp away from a TSS were selected, scaled to the same length, and represented as in B. D) Difference between the corrected and raw signals. Genes were scaled and aligned as in Fig. 1a, b. The Y-axis represents the logarithm of the p value of the difference. Two different curves are shown: one represents the positive difference values, i.e., those in which the raw signal was higher than the corrected signal (Dif +), and the other represents the negative difference values, i.e., those in which the raw signal was smaller than the corrected signal (Dif −).