6533b857fe1ef96bd12b458f
RESEARCH PRODUCT
Implications of irradiating the subventricular zone stem cell niche
José Manuel García-verdugoVivian Capilla-gonzalezKristin J. RedmondAlfredo Quinones-hinojosaJanice M. Bonsusubject
NeurogénesisNeoplasias encefálicasCarcinogenesisSubventricular zoneNeurogenesis:Diseases::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms [Medical Subject Headings]Brain tumorSubventricular zoneBrain damageBiologyBrain tumorsArticle03 medical and health sciencesLateral ventricles0302 clinical medicineRadioterapiaLateral VentriclesGliomamedicineAnimalsHumans:Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms Nerve Tissue::Neuroectodermal Tumors::Neoplasms Neuroepithelial::Glioma [Medical Subject Headings]Stem Cell Nichelcsh:QH301-705.5:Anatomy::Cells::Stem Cells::Neural Stem Cells [Medical Subject Headings]Medicine(all)Neural stem cellsRadiationDentate gyrus:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Radiotherapy [Medical Subject Headings]NeurogenesisBrainCell BiologyGeneral MedicineAnatomymedicine.diseaseCélulas-madre neuralesNeural stem cellBrain tumormedicine.anatomical_structurelcsh:Biology (General)nervous system030220 oncology & carcinogenesis:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis::Disease-Free Survival [Medical Subject Headings]medicine.symptomNeuroscience030217 neurology & neurosurgeryDevelopmental Biologydescription
Radiation therapy is a standard treatment for brain tumor patients. However, it comes with side effects, such as neurological deficits. While likely multi-factorial, the effect may in part be associated with the impact of radiation on the neurogenic niches. In the adult mammalian brain, the neurogenic niches are localized in the subventricular zone (SVZ) of the lateral ventricles and the dentate gyrus of the hippocampus, where the neural stem cells (NSCs) reside. Several reports showed that radiation produces a drastic decrease in the proliferative capacity of these regions, which is related to functional decline. In particular, radiation to the SVZ led to a reduced long-term olfactory memory and a reduced capacity to respond to brain damage in animal models, as well as compromised tumor outcomes in patients. By contrast, other studies in humans suggested that increased radiation dose to the SVZ may be associated with longer progression-free survival in patients with high-grade glioma. In this review, we summarize the cellular and functional effects of irradiating the SVZ niche. In particular, we review the pros and cons of using radiation during brain tumor treatment, discussing the complex relationship between radiation dose to the SVZ and both tumor control and toxicity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-03-01 | Stem Cell Research |