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RESEARCH PRODUCT
Are Polyfunctional Cells Protective in M. tuberculosis Infection?
Francesco DieliNadia Caccamosubject
0303 health sciencesTuberculosisbiologybusiness.industryHuman immunodeficiency virus (HIV)Diseasemedicine.disease_causebiology.organism_classificationmedicine.diseaseClinical diseaseAsymptomaticVirology3. Good healthMycobacterium tuberculosis03 medical and health sciences0302 clinical medicinemedicineTuberculosis controlmedicine.symptombusinessPathogen030304 developmental biology030215 immunologydescription
Tuberculosis (TB) continues to claim almost 2 million lives each year, and causes active TB disease in over 9 million new cases yearly. Control of TB is further impeded by the strong increase in TB morbidity and mortality due to HIV co-infection, and the rise of multi-drug resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (Mtb) strains (WHO. Global tuberculosis control: surveillance, planning, financing: WHO 10 report 2008). Clinical disease does not develop in the vast majority (90-98%) of all Mtb infected individuals, providing compelling evidence that the human system is capable of controlling the pathogen. However, these clinically asymptomatic subjects do not achieve sterile eradication of the pathogen and consequently remain latently infected lifelong, but 2-10% of them will progress to developing TB during their lifetime.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-02-24 |