6533b857fe1ef96bd12b45f9
RESEARCH PRODUCT
Bacterial Cytolysin Perturbs Round Window Membrane Permeability Barrier In Vivo: Possible Cause of Sensorineural Hearing Loss in Acute Otitis Media
Frank EngelRosemarie BlatzMichael PalmerSucharit BhakdiReinhard Schliebssubject
Membrane permeabilityHearing lossHearing Loss SensorineuralImmunologyGuinea PigsBiologyIn Vitro TechniquesMicrobiologyPermeabilityBacterial ProteinsIn vivoAlbuminsmedicineotorhinolaryngologic diseasesAnimalsCochleaRound windowMembranesOtitis Media with EffusionAnatomyBacterial Infectionsmedicine.diseaseCochleaInfectious Diseasesmedicine.anatomical_structureRound Window EarStreptolysinsBiophysicsMiddle earParasitologySensorineural hearing lossCytolysinsense organsmedicine.symptomdescription
ABSTRACT The passage of radioiodinated streptolysin-O (SLO) and albumin through the round window membrane (RWM) was studied in vivo. When applied to the middle ear, SLO became quantitatively entrapped in this compartment and no passage to the cochlea occurred. However, flux of radioiodinated albumin through the toxin-damaged RWM was observed. We propose that the passage of noxious macromolecules, such as proteases, from a purulent middle-ear effusion may be facilitated by pore-forming toxins, resulting in cochlear damage and sensorineural hearing loss.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-01-01 |