6533b857fe1ef96bd12b4623
RESEARCH PRODUCT
Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy
S. CevoliPietro CortelliPasquale MontagnaCaterina TononBruno BarbiroliGiulia PierangeliFabiola MagnificoRaffaele LodiClaudia TestaGiulia Bivonasubject
AdultMalemedicine.medical_specialtyMagnetic Resonance SpectroscopyHypothalamusCluster HeadacheCreatineCentral nervous system diseasechemistry.chemical_compoundParietal LobeInternal medicinemedicineHumansIn patientBRAINAgedCerebral CortexNeuronsAspartic AcidSPECTROSCOPYVascular diseasebusiness.industryCluster headacheproton MRMetabolismMiddle AgedCreatinemedicine.diseasehypothalamuDYSFUNCTIONProton mr spectroscopyEndocrinologychemistryHypothalamusAcute DiseaseChronic DiseaseFemaleOccipital LobeNeurology (clinical)ProtonsbusinessmetabolismBiomarkersdescription
The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-01-01 | Neurology |