Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors

6533b857fe1ef96bd12b4663

RESEARCH PRODUCT

Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors

Sascha Jung Petrine Wellendorph Gitte M. Knudsen Anne S. Haugaard Elina T. L’estrade Christina Birkedahl Falk-petersen Bente Fro Lund Matthias M. Herth Matthias M. Herth Nane Griem-krey Tomas Ohlsson Maria Erlandsson Hartmut Lüddens Tanja Schirmeister Hanne D. Hansen

subject

GABAA receptor Stereochemistry General Chemical Engineering General Chemistry Aminobutyric acid Imaging agent lcsh:Chemistry chemistry.chemical_compound lcsh:QD1-999 chemistry Radioligand Penetrant (biochemical)Benzamide Receptor Preclinical imaging

description

The α4/6βδ-containing GABAA receptors are involved in a number of brain diseases. Despite the potential of a δ-selective imaging agent, no PET radioligand is currently available for in vivo imaging...

year	journal	country	edition	language
2019-05-01	ACS Omega

https://doi.org/10.1021/acsomega.9b00434

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