6533b857fe1ef96bd12b4734
RESEARCH PRODUCT
Stress and immune response to bacterial LPS in the sea urchin Paracentrotus lividus (Lamarck, 1816).
Mirella VazzanaLuigi IngugliaAlan DeidunVincenzo ArizzaMarco Chiaramontesubject
0301 basic medicineLipopolysaccharidesPhagocytosisAntimicrobial peptidesAquatic ScienceParacentrotus lividusAntimicrobical peptide03 medical and health sciencesImmune systemStress PhysiologicalHeat shock proteinbiology.animalEnvironmental ChemistryHSP90AnimalsSea urchinHSP70Heat-Shock ProteinsbiologyEchinoderm04 agricultural and veterinary sciencesGeneral Medicinebiology.organism_classificationHsp90Immunity InnateHsp70Cell biologyThymosin030104 developmental biologyImmune System040102 fisheriesbiology.proteinParacentrotus0401 agriculture forestry and fisheriesCoelomocyteParacentrotus lividudescription
The immune system of the sea urchin species Paracentrotus lividus is highly complex and, as yet, poorly understood. P. lividus coelomocytes mediate immune response through phagocytosis and encapsulation of non-self particles, in addition to the production of antimicrobial molecules. Despite this understanding, details of exactly how these processes occur and the mechanisms which drive them are still in need of clarification. In this study, we show how the bacterial lipopolysaccharides (LPS) is able to induce a stress response which increases the levels of the heat shock proteins HSP70 and HSP90 only a few hours after treatment. This study also shows that LPS treatment increases the expression of the beta-thymosin-derivated protein paracentrin, the precursor of antimicrobial peptides.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-12-20 | Fishshellfish immunology |