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Abstract Background/Objective Assessments of health can be biased by response shift effects. One method for detecting such effects is the use of anchoring vignettes. The aim of this study was to analyze the relationship between participants’ self-assessed health state and their assessments of these vignettes. Method A total of 342 cardiovascular patients assessed their own state of health on a 0-100 visual analogue scale. The patients additionally assessed two vignettes featuring fictional persons suffering from specific complaints. A sample of the general population (N = 1,236) served as controls. Results The participants rated the health state of the vignette character featuring physical problems as being significantly better than the general population did (effect size: d = 0.53). The group difference in the assessment of the vignette featuring primarily mental health problems was lower (d = -0.17). Participants’ assessments of the vignettes were positively correlated with their assessments of their own health state (r = .26 and r = .10) and with several quality of life variables. Conclusions Anchoring vignettes are a useful tool for detecting response shift effects.