6533b857fe1ef96bd12b4ed7

RESEARCH PRODUCT

Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies

Tana OmokokoÖZlem TüreciPetra SimonUgur Sahin

subject

epitopeAdoptive cell transferImmunologyT-cell receptorhemic and immune systemschemical and pharmacologic phenomenaComputational biologyBiologypersonalized immunotherapybiological factorsEpitopeOncologyAntigen specificImmunologyImmunology and AllergyT cell engineeringT cell receptorAuthor's Viewtissuesadoptive cell transfer

description

We have developed a highly versatile platform for the systematic retrieval of T-cell receptors (TCRs) from single-antigen-reactive T cells and for characterization of their function and specificity. This approach enables rapid extraction of multiple TCRs from repertoires in individuals and not only broadens the diversity of TCRs suitable for clinical use, but also sets the stage for actively personalized immunotherapeutic strategies.

yearjournalcountryeditionlanguage
2015-01-04OncoImmunology
https://doi.org/10.1080/2162402x.2015.1005523