6533b857fe1ef96bd12b5061

RESEARCH PRODUCT

Mandibular destructive radiolucent lesion: the first sign of multiple myeloma

Danyel-elias-da Cruz PerezAmanda-almeida LeiteFlávia-maria-de Moraes Ramos-perezEduardo-rodrigues FregnaniAna-cristina-alo NesrallahClaudia-joffily Parahyba

subject

medicine.medical_specialtyRadiodensityCase ReportOdontologíaLesion03 medical and health sciences0302 clinical medicinestomatognathic systemBiopsymedicineGeneral DentistryMultiple myelomaOral Medicine and Pathologymedicine.diagnostic_testbusiness.industry030206 dentistrymedicine.diseaseCiencias de la saludTransplantationmedicine.anatomical_structure030220 oncology & carcinogenesisUNESCO::CIENCIAS MÃ DICASCortical boneRadiologyBone marrow:CIENCIAS MÃ DICAS [UNESCO]Differential diagnosismedicine.symptombusiness

description

The occurrence of a mandibular lesion as the first sign of multiple myeloma (MM) is uncommon. This report describes a case of MM diagnosed because of a mandibular lesion. A 62-year-old woman presented a destructive radiolucent lesion in the right mandibular ramus. The lesion caused rupture of the anterior cortical bone and extended from the retromolar area to the coronoid process. An incisional biopsy was performed. Histopathological examination revealed numerous pleomorphic plasma cells, some with binucleated nuclei. The tumor cells showed kappa light-chain restriction. Bone marrow biopsy showed findings of massive infiltration of neoplastic plasma cells, besides lesions in the vertebrae. The diagnosis of MM was established. The patient underwent autologous hematopoietic stem-cell transplantation. Currently, the patient is under regular follow up after 40 months of initial treatment. In conclusion, MM should be considered in the differential diagnosis of destructive mandibular lesions. Key words:Mandible, multiple myeloma, radiolucent lesion.

yearjournalcountryeditionlanguage
2016-10-01
http://hdl.handle.net/10550/57541