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RESEARCH PRODUCT

Left ventricular hypertrophy in chronic kidney disease: A diagnostic criteria comparison.

Maurizio AvernaGiuseppe MulèAlessandro MattinaGiulio GeraciEmilio NardiChiara NardiAntonina Giammanco

subject

AdultMalemedicine.medical_specialtyEndocrinology Diabetes and Metabolismmedicine.medical_treatmentPopulationMedicine (miscellaneous)030209 endocrinology & metabolismBlood Pressure030204 cardiovascular system & hematologyurologic and male genital diseasesLeft ventricular hypertrophyRisk AssessmentVentricular Function Left03 medical and health sciencesNormal renal functionYoung Adult0302 clinical medicineInternal medicinePrevalenceMedicineHumansLeft ventricular geometryIn patientcardiovascular diseasesStage (cooking)Renal Insufficiency ChroniceducationDialysisAgededucation.field_of_studyNutrition and DieteticsVentricular Remodelingbusiness.industryMiddle Agedmedicine.diseaseCKD Echocardiography Hypertension Letf ventricular hypertrophy Ventricular geometryCross-Sectional StudiesItalyHeart Disease Risk FactorsHypertensionCardiologyFemaleHypertrophy Left VentricularEssential HypertensionCardiology and Cardiovascular MedicinebusinessKidney disease

description

Background and aims: CKD patients have a high prevalence of LVH and this leads to an increase of cardiovascular risk. The aim of this study was to assess the prevalence of left ventricular hypertrophy (LVH) and left ventricular geometry in a group of 293 hypertensive patients with stage 2–5 chronic kidney disease (CKD), compared with 289 essential hypertensive patients with normal renal function. Methods and results: All patients underwent echocardiographic examination. Patients on stage 1 CKD, dialysis treatment, or with cardiovascular diseases were excluded. LVH was observed in 62.8% of patients with CKD and in 51.9% of essential hypertensive patients (P < 0.0001). We found increasingly higher left ventricular diameters, thicknesses, and mass from stage 2–5 CKD. Distribution of concentric and eccentric LVH was not very different between the two groups. However, after introducing mixed hypertrophy, the difference between the two groups group was disclosed (P = 0.027). Multiple regression analysis confirmed that the association between renal function and left ventricular mass (β −0.287; P < 0.0001) was independent by potential confounders. Diastolic function was significantly worse in patients with CKD, especially in more advanced stages. Conclusion: Our study confirms that LVH is highly prevalent in patients with CKD, especially by using the most recent cut off; in this population, LVH is often characterized by the simultaneous increase of wall thicknesses and diameters with negative effects on diastolic function.

yearjournalcountryeditionlanguage
2020-06-16Nutrition, metabolism, and cardiovascular diseases : NMCD
10.1016/j.numecd.2020.08.028https://pubmed.ncbi.nlm.nih.gov/33092976