6533b857fe1ef96bd12b5106
RESEARCH PRODUCT
A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia
Alessandro LandiConcetta AlafaciGiovanni Grassosubject
trigeminal ganglionlcsh:Biochemistry03 medical and health sciencesTrigeminal ganglion0302 clinical medicineaction potentialTrigeminal neuralgianeurovascualr compressionGeneticsmedicinelcsh:QD415-436Molecular BiologyPathologicalTrigeminal neuralgia; action potential; molecular mechanism; neurovascualr compression; trigeminal ganglionGenetics (clinical)Trigeminal nervebusiness.industrySodium channellcsh:RM1-950medicine.diseasePathophysiologylcsh:Therapeutics. Pharmacology030220 oncology & carcinogenesisAnesthesiaNeuropathic painMolecular MedicineBrainstemmolecular mechanismbusinessNeuroscience030217 neurology & neurosurgeryTrigeminal neuralgiaResearch Articledescription
Trigeminal neuralgia (TN) is a form of neuropathic pain that affects the fifth cranial nerve, the most widely distributed nerve in the head. Although TN has been associated with a variety of pathological conditions, neurovascular compression on the trigeminal nerve, as it exits the brain stem, is the most frequent reported cause. This compression provides a progressive demyelination of the nerve and a subsequent aberrant neural transmission. Although several studies have clarified some physiopathological mechanisms underlying TN, the molecular basis remains vague. Very recently the substitution of methionine 136 by valine (MET126Val) in sodium channel Nav1.6 in a case study of typical TN has suggested a new possible mechanism for TN. The findings of this new mutation provide novel information that warrants further conclusive investigations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-08-01 |