6533b858fe1ef96bd12b57b1
RESEARCH PRODUCT
A new strategy for the synthesis of highly functionalised fluorinated compounds by reaction of lithium dianions of carboxylic acids with perfluoroketene dithioacetals
Jean-philippe BouillonSalvador GilMargarita ParraEnrique SotocaEnrique SotocaCharles Portellasubject
chemistry.chemical_compoundTrifluoromethylchemistryOrganic ChemistryDrug DiscoverySynthonchemistry.chemical_elementLithiumBiochemistryMedicinal chemistryFluoridedescription
The reaction of perfluoroketene dithioacetal with lithium dienediolates of carboxylic acids proceeds at the ω position probably through an addition to the π system followed by elimination of the vinylic fluoride. The preparative value of this reaction depends strongly on the reaction and work-up conditions. The overall process lead to highly functionalised synthons containing a trifluoromethyl group.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-05-01 | Tetrahedron |