6533b858fe1ef96bd12b5867
RESEARCH PRODUCT
Mouse models of inflammatory bowel disease.
Stefan WirtzMarkus F. Neurathsubject
STAT3 Transcription FactorPharmaceutical ScienceMice Transgenicdigestive systemInflammatory bowel diseasePathogenesisMiceImmune systemImmunityMedicineAnimalsHumansCrohn's diseasebusiness.industryCrohn diseaseNF-kappa BSTAT4 Transcription Factormedicine.diseaseCadherinsInflammatory Bowel DiseasesUlcerative colitisdigestive system diseasesPathophysiologyImmunity InnateInterleukin-10Disease Models AnimalImmunologybusinessdescription
Animal models of intestinal inflammation are indispensable for our understanding of the pathogenesis of Crohn disease and Ulcerative colitis, the idiopathic forms of inflammatory bowel disease in humans. The clinical appearance of human IBD is heterogeneous, a fact that is also reflected by the steadily increasing number of mouse strains displaying IBD like intestinal alterations. The analysis of these models together with genetic studies in humans greatly enhanced our insights into immunoregulatory processes in the gut and led to the generally accepted hypothesis that a deregulated immune response against components of the intestinal microbiota is critically involved in IBD pathophysiology. In this article we provide a brief overview of selected mouse models of IBD and discuss their contribution to the current understanding of disease mechanisms that contribute to IBD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-05-12 | Advanced drug delivery reviews |