6533b858fe1ef96bd12b58ce
RESEARCH PRODUCT
Preformulation: Effect of Moisture Content on Microcrystalline Cellulose (Avicel PH-302) and Its Consequences on Packing Performances
Odile ChambinY. PourcelotV. NicolasM. H. Rochat-gonthierC. Andrèssubject
Materials scienceChemistry PharmaceuticalPharmaceutical SciencePlasticityDosage formExcipientschemistry.chemical_compoundDrug DiscoveryCelluloseCelluloseWater contentPharmacologyChromatographyOrganic ChemistryWaterHumidityCompression (physics)Microcrystalline celluloseKineticschemistryChemical engineeringStress MechanicalParticle sizePowdersRheologyPlasticsTabletsdescription
This study evaluates the influence of moisture content on the packing performances of a new grade of microcrystalline cellulose (MCC) (Avicel PH-302) either by classical method or by an unconventional compression technique (constant volume reduction of powder bed). An increase in moisture content decreases the apparent density of the powder bed, resulting from interparticulate friction enhancement. This modification of apparent density seems to be the main effect caused by the presence of humidity, which explains the variations of compression properties, like an increase of powder plasticity generally observed in the experimental conditions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-10-26 | Drug Development and Industrial Pharmacy |