Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein

6533b858fe1ef96bd12b594d

RESEARCH PRODUCT

Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein

Stéphane Bertagnoli C. Boucraut-baralon E. Boilletot Alain Milon Jean-françois Vautherot Denis Rasschaert F. Petit S. Laurent Jacqueline Gelfi G Le Gall

subject

RNA viruses Hemorrhagic Disease Virus Rabbit animal diseases viruses Leporipoxvirus law.invention 0403 veterinary science law VIRUS RECOMBINE ComputingMilieux_MISCELLANEOUS Caliciviridae Infections [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology 0303 health sciences Vaccines Synthetic Myxomatosis Lagovirus 04 agricultural and veterinary sciences 3. Good health Lagovirus Capsid [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Recombinant DNA cardiovascular system Rabbits Reassortant Viruses Leporipoxvirus Research Article 040301 veterinary sciences Immunology DNA Recombinant Myxoma virus Biology Microbiology Virus 03 medical and health sciences Myxomatosis Infectious Immunity reactions Virology Reassortant Viruses medicine Animals Rabbit diseases Recombinant vaccines cardiovascular diseases Immune response 030304 developmental biology Viral Structural Proteins Viral infections Myxoma virus biology.organism_classification medicine.disease Virology Médecine vétérinaire et santé animal Insect Science Experimental infections DNA Viral DNA viruses

description

Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease. These recombinant viruses expressed the RHDV capsid protein (VP60). The recombinant protein, which is 60 kDa in size, was antigenic, as revealed by its reaction in immunoprecipitation with antibodies raised against RHDV. Both recombinant viruses induced high levels of RHDV- and myxoma virus-specific antibodies in rabbits after immunization. Inoculations by the intradermal route protected animals against virulent RHDV and myxoma virus challenges.

year	journal	country	edition	language
1996-08-01	Journal of virology

https://oatao.univ-toulouse.fr/754/

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