6533b858fe1ef96bd12b5a23
RESEARCH PRODUCT
The Mitochondrial Antioxidant SS-31 Modulates Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Type 2 Diabetes
Pedro DíazZaida Abad-jiménezVictor M. VictorSandra López-domènechIrene Escribano-lopezFrancesca IannantuoniNadezda ApostolovaMilagros RochaAranzazu M. De MarañónEva Solásubject
medicine.medical_specialtyautophagyendocrine system diseaseslcsh:MedicineCHOPMitochondrionmedicine.disease_causeArticle03 medical and health sciences0302 clinical medicineInternal medicinemedicineoxidative stress030304 developmental biologychemistry.chemical_classification0303 health sciencesReactive oxygen speciesbusiness.industrySS-31Endoplasmic reticulumAutophagylcsh:Rnutritional and metabolic diseasesGeneral MedicineBECN1MitochondriaEndocrinologychemistry030220 oncology & carcinogenesisUnfolded protein responseendoplasmic reticulum stresstype 2 diabetesbusinessOxidative stressdescription
Mitochondrial dysfunction has been shown to play a central role in the pathophysiology of type 2 diabetes (T2D), and mitochondria-targeted agents such as SS-31 are emerging as a promising strategy for its treatment. We aimed to study the effects of SS-31 on leukocytes from T2D patients by evaluating oxidative stress, endoplasmic reticulum (ER) stress and autophagy. Sixty-one T2D patients and 53 controls were included. Anthropometric and analytical measurements were performed. We also assessed reactive oxygen species (ROS) production, calcium content, the expression of ER stress markers GRP78, CHOP, P-eIF2&alpha
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-08-01 | Journal of Clinical Medicine |