6533b858fe1ef96bd12b5ad3

RESEARCH PRODUCT

Quality of life improving after propranolol treatment in patients with Infantile Hemangiomas

Marco PensabeneMaria Rita Di PaceFabio BaldanzaFrancesco GrassoMaria PattiMaria SergioSimona La PlacaMario Giuffre’Gregorio SerraAlessandra CasuccioMarcello Cimador

subject

Skin NeoplasmsTreatment OutcomeDrug-Related Side Effects and Adverse ReactionsSurveys and QuestionnairesQuality of LifeAdministration OralHumansInfantHemangioma CapillaryGeneral MedicinePropranololIH Quality of life Pediatric benign tumors Propranolol Questionnaire

description

AbstractInfantile hemangiomas may affect the quality of life (QoL) of patients and their family members, as anxiety and worry may commonly occur in parents, also linked to the social adversion they experience. We underline the beneficial impact of oral propranolol therapy on QoL of patients with infantile hemangiomas (IH) and of their relatives. A specific questionnaire measuring QoL was administered to parents of IH patients at beginning and end of a treatment with oral propranolol. Different aspects were investigated: site of the lesion, age of patients at starting therapy, length of treatment, occurrence of adverse effects and persistence/recurrence of the vascular anomaly. In all cases the questionnaire revealed a significant improvement of QoL, which was independent from all analyzed factors. It showed that oral propranolol administration in these patients combines optimal clinical results with relevant improvement of QoL, especially in cases of early management. The improvement of QoL seems unrelated to site of lesion, timing and duration of therapy, occurrence of drug-related adverse effects and persistence/recurrence of disease.

yearjournalcountryeditionlanguage
2022-08-04
10.1186/s13052-022-01334-2http://hdl.handle.net/10447/566255