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RESEARCH PRODUCT
Stereoselective Synthesis of the Cytotoxic Macrolide FD-891
Jorge Garcia‐fortanetJuan MurgaJ. Alberto MarcoMiguel Cardasubject
Molecular StructureChemistryStereochemistryOrganic ChemistryTotal synthesisAntineoplastic AgentsStereoisomerismGeneral MedicineRing (chemistry)BiochemistryAldol reactionCytotoxic T cellStereoselectivityMacrolidesPhysical and Theoretical Chemistrydescription
[reaction: see text] A total synthesis of the naturally occurring, cytotoxic macrolide FD-891 is described. Three fragments were first stereoselectively constructed using mainly asymmetric aldol and allylation reactions. The complete framework was then assembled using two Julia-Kocienski olefinations to connect the three fragments and a Yamaguchi reaction to close the macrolactone ring.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-05-20 | Organic Letters |