6533b858fe1ef96bd12b6386
RESEARCH PRODUCT
Terpenoid treatment in osteoporosis: this is where we have come in research.
Carla GentileFabio CaradonnaRiccardo AlessandroViviana CostaAngela De LucaGianluca GiavaresiEufrosina DimarcoValeria CarinaMilena FiniLavinia RaimondiDaniele Bellaviasubject
Endocrinology Diabetes and MetabolismOsteoporosisBioinformaticsBone resorptionBone and BonesFractures BoneEndocrinologyOsteoclastterpenoidsSettore BIO/13 - Biologia ApplicataSettore BIO/10 - Biochimicamedicinebone erosive diseasesHumansBone formationBone ResorptionProgressive osteopeniaepigeneticsbusiness.industryTerpenesOsteoporosis preventionOsteoblastmedicine.diseaseSettore BIO/18 - Geneticamedicine.anatomical_structureosteoclastosteoblastOsteoporosisbusinessdescription
Lower bone resistance to load is due to the imbalance of bone homeostasis, where excessive bone resorption, compared with bone formation, determines a progressive osteopenia, leading to a high risk of fractures and consequent pain and functional limitations. Terpenoids, with their activities against bone resorption, have recently received increased attention from researchers. They are potentially more suitable for long-term use compared with traditional therapeutics. In this review of the literature of the past 5 years, we provide comprehensive information on terpenoids, with their anti-osteoporotic effects, highlighting molecular mechanisms that are often in epigenetic key and a possible pharmacological use in osteoporosis prevention and treatment.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-11-01 | Trends in endocrinology and metabolism: TEM |