6533b858fe1ef96bd12b63bf
RESEARCH PRODUCT
The importance of transmembrane domain interactions in the viral control of apoptosis
Gerard DuartLuis Martínez-gilIsmael Mingarrosubject
0301 basic medicineCancer ResearchViral proteinChemistryvirusesmedicine.diseasemedicine.disease_cause030112 virologyTransmembrane proteinLymphomaCell biology03 medical and health sciencesTransmembrane domain030104 developmental biologyimmune system diseasesApoptosishemic and lymphatic diseasesAuthor’s ViewsmedicineMolecular Medicinebiological phenomena cell phenomena and immunityneoplasmsFunction (biology)description
Viral control of apoptosis occurs through the expression of viral encoded anti-apoptotic B-cell lymphoma 2 (BCL2) analogs. These proteins are thought to restrain apoptosis by interacting with cellular BCL2 family members. We identified that protein-protein interactions between cellular and viral BCL2 transmembrane domains are crucial for the viral protein’s function.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-05-24 | Molecular & Cellular Oncology |