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RESEARCH PRODUCT
4-Hydroxynonenal, a lipid peroxidation product, induces relaxation of human cerebral arteries.
M. Carmen Román MartínezMartin AldasoroFrancisco J. RomeroFrancisco Bosch-morellJoaquín RomáAngel RayaSalvador LluchJosé Vilasubject
MaleLipid PeroxidesContraction (grammar)EndotheliumIndomethacinCerebral arteriesStimulationVasodilationArginineDinoprostNitric Oxide4-HydroxynonenalNitric oxideLipid peroxidationchemistry.chemical_compoundCadavermedicineHumansAgedAged 80 and overAldehydesDose-Response Relationship DrugChemistryOsmolar ConcentrationCerebral ArteriesMiddle AgedVasodilationNG-Nitroarginine Methyl Estermedicine.anatomical_structureNeurologyBiochemistryBiophysicsEndothelium VascularNeurology (clinical)Cardiology and Cardiovascular Medicinedescription
The relaxant effect of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, on human cerebral arteries was studied. Addition of 4-HNE to artery rings promoted no contraction, and after stimulation with prostaglandin F2α (PFG2α; 10−7-3 × 10−6 M), 100% relaxation was obtained with 3 × 10−5 M 4-HNE. Inhibition of nitric oxide formation with NG-nitro-l-arginine methyl ester hydrochloride (l-NAME; (10−4 M), as well as prostaglandin synthesis with indomethacin (3 × 10−6 M), partially prevented 4-HNE-induced relaxation, but each of these substances separately failed to inhibit complete relaxation. Addition of both inhibitors together reduced 4-HNE-induced relaxation to ≈50%, but relaxation could not be abolished. When the endothelium was removed, 4-HNE did not promote relaxation after PGF2α stimulation. The possible roles of different intracellular signaling systems in the vascular effect of 4-HNE are discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-07-01 |