6533b858fe1ef96bd12b64f4
RESEARCH PRODUCT
Anti-Pseudomonas aeruginosa activity of hemlock (Conium maculatum, Apiaceae) essential oil
Adriana BasileFilippo MaggiAnna ZanfardinoMaurizio BrunoMichela Di NapoliMario Varcamontisubject
Anti-Infective AgentAlkeneved/biology.organism_classification_rank.speciesPlant Sciencemedicine.disease_cause01 natural sciencesBiochemistryConium maculatumessential oilGas Chromatography-Mass SpectrometryAnalytical Chemistrylaw.inventionchemistry.chemical_compoundPiperidinelawBotanymedicineEscherichia coliOils Volatilechemical compositionSicilyEssential oilDistillationAcyclic MonoterpeneApiaceaeantimicrobial activitybiology010405 organic chemistryved/biologyPseudomonas aeruginosaMicrobial Sensitivity TestOrganic ChemistryConium maculatumAntimicrobialbiology.organism_classificationHemlock0104 chemical sciences010404 medicinal & biomolecular chemistrychemistryMyrcenePseudomonas aeruginosaComposition (visual arts)WeedPlant LeaveApiaceaedescription
Conium maculatum is a nitrophilous weed belonging to the Apiaceae family and occurring in hedgerows, pastures, waste ground, along rivers and roadsides. Little is known on the chemistry and bioactivity of other secondary metabolites occurring in the plant. In the present work, we have analysed the chemical composition and antimicrobial activity of the essential oils hydrodistilled from leaves and inflorescenes of C. maculatum growing in Sicily, Italy. The composition of essential oils was achieved by gas chromatography-mass spectrometry (GC-MS) analysis, whereas the inhibitory effects on the growth of two Gram negative strains, namely Escherichia coli and Pseudomonas aeruginosa were assessed by two different analysis. The essential oils exhibited different chemical profiles (1-butylpiperidine and myrcene in the inflorescenes), (mostly (E)-caryophyllene in the leaves). The latter oil was particularly active in inhibiting the growth of P. aeruginosa. These results shed light on the possible application of hemlock essential oils as antimicrobial agents.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-05-21 |