6533b858fe1ef96bd12b6562
RESEARCH PRODUCT
Clinical features and comorbidity pattern of HCV infected migrants compared to native patients in care in Italy: A real-life evaluation of the PITER cohort
Maria Giovanna QuarantaLuigina FerrignoXhimi TataFranca D'angeloMarco MassariCarmine CoppolaElisa BiliottiAlessia GiorginiDiletta LaccabueAlessia CiancioPier Luigi BlancMarzia MargottiDonatella IeluzziMaurizia Rossana BrunettoFrancesco BarbaroFrancesco Paolo RussoIlaria BerettaGiulia MorsicaGabriella VerucchiAnnalisa SaracinoMassimo GalliLoeta A. KondiliCesare MazzaroManuela BertolaOrnella SchioppaAntonio BenedettiLaura SchiadàMonica CuccoAndrea GiacomettiLaura BresciniSefora CastellettiAlessandro FiorentiniGioacchino AngaranoMichele MilellaAlfredo Di LeoMaria RendinaFulvio Salvatore D'abramoChiara LilloAndrea IannoneMariano PiazzollaGabriella VerucchiLorenzo BadiaFabio PiscagliaFrancesca BeneventoIlaria SerioFrancesco CastelliSerena ZaltronAngiola SpinettiSilvia OdoliniRaffaele BrunoMario U. MondelliLuchino ChessaMartina LoiCarlo TortiChiara CostaMaria MazzitelliVincenzo PisaniVincenzo ScaglioneEnrico Maria TrecarichiAnna Linda ZignegoMonica MontiFrancesco MadiaPier Luigi BlancLetizia AttalaPiera PierottiElena SalomoniElisa MariabelliTeresa Antonia SantantonioSerena Rita BrunoEster Marina CelaMatteo BassettiGiovanni MazzarelloAnna Ida AlessandriniAntonio Di BiagioLaura Ambra NicoliniGiovanni RaimondoRoberto FilomiaAlessio AghemoRossella MeliAdriano LazzarinGiulia MorsicaStefania SalpietroMassimo GalliAnna Ludovica FracanzaniErika FattaRosa LombardiPietro LamperticoMarta BorghiRoberta D'ambrosioElisabetta DegasperiMassimo PuotiChiara BaigueraFederico D'amicoMaria VinciMaria Grazia RumiMassimo ZuinAlessia GiorginiPaola ZermianiPietro AndreonePaolo CaraceniMarzia MargottiValeria GuarneriErica VillaVeronica BernabucciLaura BristotMaria Luisa ParadisoGuglielmo MigliorinoIlaria BerettaAlessandra GambaroGiuseppe LapadulaAnna SpoltiAlessandro SoriaPietro InvernizziAntonio CiaccioMartina LucàFederica MalinvernoLaura RattiCarmine CoppolaDaniela Caterina AmorusoFederica PisanoFerdinando ScaranoLaura StaianoFilomena MoriscoValentina CossigaIvan GentileAntonio Riccardo BuonomoMaria FoggiaEmanuela ZappuloAlessandro FedericoMarcello DallioNicola CoppolaCaterina SagnelliSalvatore MartiniCaterina MonariGerardo NardoneCostantino SgamatoLiliana ChemelloLuisa CavallettoDaniela SterrantinoFrancesco Paolo RussoAlberto ZanettoPaola ZanagaFrancesco BarbaroGiuseppina BrancaccioAntonio CraxìSalvatore PettaVincenza CalvarusoLuciano CrapanzanoSalvatore MadoniaMarco CannizzaroErica Maria BrunoAnna LicataSimona AmodeoAdele Rosaria CapitanoCarlo FerrariDiletta LaccabueElisa NegriAlessandra OrlandiniMarco PesciRoberto GulminettiLayla PagnuccoGiustino ParrutiPaola Di StefanoMaurizia Rossana BrunettoBarbara CocoMarco MassariRomina CorsiniElisa GarlassiMassimo AndreoniElisabetta TetiCarlotta CervaLorenzo BaiocchiXhimi TataGiuseppe GrassiAntonio GasbarriniMaurizio PompiliMartina De SienaGloria TalianiElisa BiliottiMartina SpazianteMarcello PersicoMario MasaroneAndrea AglittiGemma CalvaneseMarco AnselmoPasqualina De LeoMonica MarturanoGiorgio Maria SaraccoAlessia CiancioDonatella Ieluzzisubject
MaleHCV genotypesEthnic groupLinked-to-care patientComorbidityHepacivirusLogistic regressionmedicine.disease_causeComorbidities; Direct acting antivirals; HCV Cohort; Linked-to-care patients; Aged; Antiviral Agents; Coinfection; Comorbidity; Female; Hepacivirus; Hepatitis C Chronic; Humans; Italy; Male; Middle Aged; Transients and MigrantsComorbidities0302 clinical medicineMedicineComorbidities; Direct acting antivirals; HCV Cohort; Linked-to-care patientsChronicTransients and MigrantsCoinfectionGastroenterologyvirus diseasesMiddle AgedHepatitis CLife evaluationItaly030220 oncology & carcinogenesisLinked-to-care patientsCohort030211 gastroenterology & hepatologyFemaleComorbiditieHumanHepatitis C virusSettore MED/12 - GASTROENTEROLOGIAAntiviral AgentsDirect acting antivirals03 medical and health sciencesDisease severityHumansAgedAntiviral AgentHepaciviruHepatologybusiness.industrySettore MED/09 - MEDICINA INTERNAHepatitis C Chronicmedicine.diseaseComorbiditydigestive system diseasesDirect acting antiviralHCV CohortbusinessDemographydescription
Background: Direct-acting antivirals are highly effective for the treatment of hepatitis C virus (HCV) infection, regardless race/ethnicity. We aimed to evaluate demographic, virological and clinical data of HCV-infected migrants vs. natives consecutively enrolled in the PITER cohort. Methods: Migrants were defined by country of birth and nationality that was different from Italy. Mann-Whitney U test, Chi-squared test and multiple logistic regression were used. Results: Of 10,669 enrolled patients, 301 (2.8%) were migrants: median age 47 vs. 62 years, (p < 0.001), females 56.5% vs. 45.3%, (p < 0.001), HBsAg positivity 3.8% vs. 1.4%, (p < 0.05). Genotype 1b was prevalent in both groups, whereas genotype 4 was more prevalent in migrants (p < 0.05). Liver disease severity and sustained virologic response (SVR) were similar. A higher prevalence of comorbidities was reported for natives compared to migrants (p < 0.05). Liver disease progression cofactors (HBsAg, HIV coinfection, alcohol abuse, potential metabolic syndrome) were present in 39.1% and 47.1% (p > 0.05) of migrants and natives who eradicated HCV, respectively. Conclusion: Compared to natives, HCV-infected migrants in care have different demographics, HCV genotypes, viral coinfections and comorbidities and similar disease severity, SVR and cofactors for disease progression after HCV eradication. A periodic clinical assessment after HCV eradication in Italians and migrants with cofactors for disease progression is warranted.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-12-01 |