Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9

6533b858fe1ef96bd12b65c9

RESEARCH PRODUCT

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9

Cristiana Guiducci Mario P. Colombo Franck J. Barrat Sabina Sangaletti Claudio Tripodo Robert L. Coffman Mei Gong

subject

Male Mice 129 Strain Immunology Gene Expression Inflammation chemical and pharmacologic phenomena Mice Inbred Strains Receptor Interferon alpha-beta Biology Skin Diseases Article Proinflammatory cytokine Pathogenesis TLR9 Mice Autoimmune skin inflammation immune system diseases Nucleic Acids medicine Immunology and Allergy Animals Lupus Erythematosus Systemic Receptor skin and connective tissue diseases TLR7 Skin Autoimmune skin inflammation; TLR7; TLR9; plasmacytoid dendritic cells.Mice Knockout Plasmacytoid dendritic cell activation Lupus erythematosus Reverse Transcriptase Polymerase Chain Reaction TLR9 virus diseases hemic and immune systems TLR7 DNA Dendritic Cells medicine.disease Flow Cytometry Mice Inbred C57BL plasmacytoid dendritic cells.Toll-Like Receptor 7 Toll-Like Receptor 9 Immunology Myeloid Differentiation Factor 88 Cytokines Female medicine.symptom

description

Lupus-prone mice develop a chronic inflammatory response to cutaneous injury that depends on the production of type I interferon, TLR7, and TLR9.

year	journal	country	edition	language
2010-01-01	The Journal of Experimental Medicine

10.1084/jem.20101048 http://europepmc.org/articles/PMC3005224

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