6533b858fe1ef96bd12b6bea

RESEARCH PRODUCT

Dissymmetric calix[4]arenes: Optical resolution of some conformationally fixed derivatives

William H. PirkleMoniralsadat TabatabaiVolker BöhmerSimeon T. PickardWalter Vogt

subject

PharmacologyChemistryOrganic ChemistryResolution (electron density)Analytical chemistryHigh-performance liquid chromatographyCatalysisSpectral lineSymmetry (physics)Analytical ChemistryCrystallographyDrug DiscoveryEnantiomerSpectroscopy

description

Various possibilities to obtain intrinsically chiral calix[4]arenes are discussed. The enantiomers of three 1,3-dietheresters and one monoether compound derived from dissymmetric calix[4]arenes with C4 symmetry were separated by HPLC using chiral stationary phases and characterized by their CD spectra. © 1993 Wiley-Liss, Inc.

https://doi.org/10.1002/chir.530050506