6533b858fe1ef96bd12b6d06

RESEARCH PRODUCT

Isolation and identification of the antibacterial compounds from Helichrysum stoechas.

José-luis RíosMaría-carmen RecioA. M. Villar

subject

PharmacologyMagnetic Resonance SpectroscopyPlants MedicinalbiologyBacteriaSpectrophotometry InfraredPlant ExtractsFractionationMicrobial Sensitivity TestsPharmacognosyAntimicrobialbiology.organism_classificationIsolation (microbiology)Anti-Bacterial AgentsAnti-Infective AgentsSpainDrug DiscoveryBotanyCandida albicansHelichrysum stoechasSpectrophotometry UltravioletChromatography Thin LayerAntibacterial activityBacteriaAntibacterial agent

description

Fractionation of the dicholoromethane extract of the aerial parts of Helichrysum stoechas yielded seven isolates (1-7), which exhibited varying antimicrobial activity against Gram-positive bacteria. Pure compounds 1-3 have been previously reported in the same species and 4 and 5 were identified as italipyrone and plicatipyrone, previously isolated from H. italicum and H. plicatum. The two other isolates are helipyrone (6) and homoarenol (7) mixed with related substances. Compound 6c (4,4'-dihydroxy-5,6,5',6'-tetramethyl-3,3'-methylen-di-pyr-2-one) and 6b helipyrone with one methyl substitution, have not been previously reported in other species.

yearjournalcountryeditionlanguage
1991-05-01Journal of ethnopharmacology
10.1016/0378-8741(91)90160-fhttps://pubmed.ncbi.nlm.nih.gov/1943173