6533b858fe1ef96bd12b6db8

RESEARCH PRODUCT

A model for long-term potentiation and depression

G. F. AyalaMichele MiglioreF. Alicata

subject

Neuronal PlasticityTime FactorsKinetic modelmusculoskeletal neural and ocular physiologyCognitive NeuroscienceLong-Term PotentiationModels NeurologicalHippocampusLong-term potentiationHippocampusSensory SystemsKineticsCellular and Molecular Neurosciencenervous systemSynapsesRetrograde signalingAnimalsHumansComputer SimulationPsychologyNeuroscienceMathematicsSignal Transduction

description

A computational model of long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus is presented. The model assumes the existence of retrograde signals, is in good agreement with several experimental data on LTP, LTD, and their pharmacological manipulations, and shows how a simple kinetic scheme can capture the essential characteristics of the processes involved in LTP and LTD. We propose that LTP and LTD could be two different but conceptually similar processes, induced by the same class of retrograde signals, and maintained by two distinct mechanisms. An interpretation of a number of experiments in terms of the molecular processes involved in LTP and LTD induction and maintenance, and the roles of a retrograde signal are presented and discussed.

https://doi.org/10.1007/bf00961444