0000000000255731

AUTHOR

G. F. Ayala

showing 3 related works from this author

A Kinetic Model of Short- and Long-Term Potentiation

1993

We present a kinetic model that can account for several experimental findings on short- and long-term potentiation (STP and LTP) and their pharmacological modulation. The model, which is consistent with Hebb's postulate, uses the hypothesis that part of the origin of LTP may be a consequence of an increased release of neurotransmitter due to a retrograde signal. The operation of the model is expressed by a set of irreversible reactions, each of which should be thought of as equivalent to a set of more complex reactions. We show that a retrograde signal alone is not sufficient to maintain LTP unless long-term change of the rate constant of some of the reactions is caused by high-frequency s…

chemistry.chemical_compoundArts and Humanities (miscellaneous)chemistryKinetic modelMechanism (biology)Cognitive NeuroscienceStimulationLong-term potentiationPharmacological modulationNeurotransmitterSet (psychology)NeuroscienceNeural Computation
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Transputer-based parallel system for acquisition and on-line analysis of single-fiber electromyographic signals.

1992

Abstract We describe a transputer-based system suitable for accurate measurements of single-fiber electromyographic jitter. It consists of a conventional electromyograph, a home-made interface and a commercially available transputer-based board installed within a PC/AT compatible. Taking advantage of the concurrent operation of two transputer modules, the system features simultaneous data acquisition and statistical signal processing: while data are acquired and analyzed, a real-time visualization of the signal latency and its variability is provided. In the present configuration, the system can acquire and analyze up to 40,000 consecutive action potentials, which can be grouped into up to …

Signal processingComputer scienceElectromyographyTransputerInterface (computing)Real-time computingHealth InformaticsSignal Processing Computer-AssistedSignalComputer Science ApplicationsData acquisitionMicrocomputersEvaluation Studies as TopicHumansDiagnosis Computer-AssistedSmoothingSoftwareStatistical signal processingJitterComputer methods and programs in biomedicine
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A model for long-term potentiation and depression

1995

A computational model of long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus is presented. The model assumes the existence of retrograde signals, is in good agreement with several experimental data on LTP, LTD, and their pharmacological manipulations, and shows how a simple kinetic scheme can capture the essential characteristics of the processes involved in LTP and LTD. We propose that LTP and LTD could be two different but conceptually similar processes, induced by the same class of retrograde signals, and maintained by two distinct mechanisms. An interpretation of a number of experiments in terms of the molecular processes involved in LTP and LTD induction and …

Neuronal PlasticityTime FactorsKinetic modelmusculoskeletal neural and ocular physiologyCognitive NeuroscienceLong-Term PotentiationModels NeurologicalHippocampusLong-term potentiationHippocampusSensory SystemsKineticsCellular and Molecular Neurosciencenervous systemSynapsesRetrograde signalingAnimalsHumansComputer SimulationPsychologyNeuroscienceMathematicsSignal TransductionJournal of Computational Neuroscience
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