6533b859fe1ef96bd12b6e36
RESEARCH PRODUCT
Ultrastructural causes of rupture of hand tendons in patients with rheumatoid arthritis. A transmission and scanning electron microscopic study.
Markus F. NeurathE. Stofftsubject
musculoskeletal diseasesPathologymedicine.medical_specialtymedicine.medical_treatmentSynovectomyFibrillaw.inventionArthritis RheumatoidTendonslawmedicineHumansRupture Spontaneousbusiness.industryGeneral MedicineAnatomyMiddle Agedmusculoskeletal systemmedicine.diseaseHandTendonMicroscopy Electronmedicine.anatomical_structureRheumatoid arthritisUltrastructureMicroscopy Electron ScanningUpper limbCollagenElectron microscopebusinessExtensor Digitorum Communisdescription
To identify the cause of rupture of hand tendons in patients with rheumatoid arthritis, we studied the underlying ultrastructural changes of the collagenous fibril systems. Samples of the flexor digitorum superficialis (n = 12) and the extensor digitorum communis (n = 20) were taken during tenosynovectomy. Tendons dissected at necropsy (n = 30) served as controls. Specimens were analysed by transmission and scanning electron microscopy. Interfibrillar dysplastic fibrils, "Luse bodies", and intracellular collagen were found in rheumatoid tissues. The diameters of collagen fibrils were significantly reduced compared with the control group (p0.01). The duration of the disease usually correlated well with the ultrastructural collagenous lesions. To provide optimum conditions for restoration of rheumatoid hand tendons, early synovectomy in rheumatoid patients seems warranted from the ultrastructural point of view. The alterations in collagen may explain the inadequate function of the hand tendons in patients with rheumatoid arthritis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-01-01 | Scandinavian journal of plastic and reconstructive surgery and hand surgery |