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RESEARCH PRODUCT
Alveolar gas exchange and tissue deoxygenation during exercise in type 1 diabetes patients and healthy controls.
Heikki KyröläinenAnne S. KoponenHarriet HägglundHeikki O. TikkanenJyrki M. AhoJuha PeltonenKatri Pullinensubject
Pulmonary and Respiratory MedicineAdultMalemedicine.medical_specialtyendocrine system diseasesPhysiologyMatched-Pair AnalysisPhysical activity030209 endocrinology & metabolism030204 cardiovascular system & hematology03 medical and health sciencesHemoglobins0302 clinical medicineOxygen ConsumptionReference ValuesInternal medicineHealthy controlmedicineHumansMuscle SkeletalDeoxygenationExerciseAerobic capacityType 1 diabetesSpectroscopy Near-InfraredChemistryPulmonary Gas ExchangeGeneral NeuroscienceSkeletal muscleGas exchangemedicine.diseaseAdaptation PhysiologicalSurgeryFrontal LobePulmonary Alveolimedicine.anatomical_structureDiabetes Mellitus Type 1Case-Control StudiesCardiologyExercise Testdescription
We used near-infrared spectroscopy to investigate whether leg and arm skeletal muscle and cerebral deoxygenation differ during incremental cycling exercise in men with type 1 diabetes (T1D, n=10, mean±SD age 33±7 years) and healthy control men (matched by age, anthrometry, and self-reported physical activity, CON, n=10, 32±7 years) to seek an explanation for lower aerobic capacity (˙VO2peak) often reported in T1D. T1D had lower ˙VO2peak (35±4mlkg(-1)min(-1) vs. 43±8mlkg(-1)min(-1), P0.01) and peak work rate (219±33W vs. 290±44W, P0.001) than CON. Leg muscle deoxygenation (↑ [deoxyhemoglobin]; ↓ tissue saturation index) was greater in T1D than CON at a given absolute submaximal work rate, but not at peak exercise, while arm muscle and cerebral deoxygenation were similar. Thus, in T1D compared with CON, faster leg muscle deoxygenation suggests limited circulatory ability to increase O(2) delivery as a plausible explanation for lower ˙VO2peak and earlier fatigue in T1D.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-18 | Respiratory physiologyneurobiology |