Microparticles: Modulators and biomarkers of liver disease

6533b859fe1ef96bd12b6efd

RESEARCH PRODUCT

Microparticles: Modulators and biomarkers of liver disease

Miroslaw Kornek Detlef Schuppan Detlef Schuppan

subject

Cell signaling CD14+Macrophage T cell Cell Apoptosis Cell Communication Biology Monocyte Exosome Annexin V CD4+Cell membrane Cell-Derived Microparticles medicine Humans Macrophage Ectosome CD41+Inflammation Hepatology Liver Diseases Monocyte Platelet NASH T cell Biomarker Dendritic cell CD8+Fibrosis Hepatitis C Cell biology Exosome medicine.anatomical_structure Liver Microparticle Biochemistry NAFL iNKT Biomarkers Dendritic cell

description

Division of Molecular and Translational Medicine,Dept. of Medicine I, Johannes Gutenberg University, Mainz, GermanyEmerging role of microparticlesMicroparticles (MP) have gained increasing attention as biomark-ers for various diseases. First described as platelet dust, MP wereregarded as unspeciﬁc debris [1]. However, it has become appar-ent that cell derived MP or ectosomes represent a novel route ofhorizontal communication between cells. MP are between 100–1000 nm in size and generated through cell membrane shedding(ectocytosis), a process that can be triggered by the activation ofthe complement C5b-9 complex, as shown for platelet derivedMP, or by inhibition of ﬂippase activitythroughCa

year	journal	country	edition	language
2012-11-01	Journal of Hepatology

https://doi.org/10.1016/j.jhep.2012.07.029

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