6533b859fe1ef96bd12b6f3d

RESEARCH PRODUCT

Hyaluronic Acid-Based Micelles as Ocular Platform to Modulate the Loading, Release, and Corneal Permeation of Corticosteroids

Fabio Salvatore PalumboMariano LicciardiGiovanna PitarresiGiulia Di PrimaFlavia BongiovìGaetano Giammona

subject

Materials Chemistry2506 Metals and AlloysTriamcinolone acetonidePolymers and PlasticsAdministration Ophthalmic02 engineering and technologyTriamcinolone01 natural sciencesMicelleDexamethasoneCorneachemistry.chemical_compoundDrug Delivery SystemsAdrenal Cortex HormonesHyaluronic acidMaterials ChemistryCorticosteroidAminesCells CulturedMicellesDrug CarriersChemistryPermeation021001 nanoscience & nanotechnology0210 nano-technologyDrug carriermedicine.drugBiotechnologyTranscorneal enhancerHyaluronic acidBioengineering010402 general chemistryPermeabilityBiomaterialsPolymeric micelleAmphiphilemedicineMucoadhesionAnimalsHumansGlucocorticoidsPolymers and PlasticOcular administrationBiomaterialHydrocarbons0104 chemical sciencesDrug LiberationSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoBiophysicsCattleEx vivo

description

The aim of this work is to prepare hyaluronic acid-based micelles as a platform to load corticosteroid drugs and to improve their corneal permeation after administration on the ocular surface. Three amphiphilic derivatives of hyaluronic acid (HA) are synthesized using different amounts of hexadecylamine (C16 -NH2 ). HAC16 a, HAC16 b, and HAC16 c derivatives are able to form micelles by the cosolvent evaporation method and to entrap corticosteroids (dexamethasone, triamcinolone, triamcinolone acetonide). HAC16 a and HAC16 b micelles show the best results in terms of drug loading and particle size. They are also able to improve drug release compared to free drug solution or suspension. In addition, HAC16 b micelles show an optimal mucoadhesion and compatibility with human corneal epithelial cells. In vitro and ex vivo permeation studies of drug-loaded HAC16 b micelles are performed to understand the ability of these micelles to act as penetration and/or permeation enhancers.

yearjournalcountryeditionlanguage
2017-07-26
10.1002/mabi.201700261http://hdl.handle.net/10447/249730