Extremely Low Frequency Magnetic Fields Do Not Affect LTP-Like Plasticity in Healthy Humans.

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RESEARCH PRODUCT

Extremely Low Frequency Magnetic Fields Do Not Affect LTP-Like Plasticity in Healthy Humans.

Fioravante Capone Fioravante Capone Giovanni Pellegrino Francesco Motolese Francesco Motolese Mariagrazia Rossi Mariagrazia Rossi Gabriella Musumeci Gabriella Musumeci Vincenzo Di Lazzaro

subject

brain stimulation Stimulation Biology Plasticity magnetic fields 050105 experimental psychology lcsh:RC321-571 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Neuroplasticity medicine Premovement neuronal activity 0501 psychology and cognitive sciences skin and connective tissue diseases lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry long-term potentiation 05 social sciences Long-term potentiation extremely low-frequency magnetic fields respiratory system Brief Research Report Psychiatry and Mental health Neuropsychology and Physiological Psychology medicine.anatomical_structure Neurology Brain stimulation plasticity Synaptic plasticity low frequency Neuroscience 030217 neurology & neurosurgery Motor cortex Neuroscience

description

Introduction: Several studies explored, in vitro, the biological effects of extremely low-frequency magnetic fields (ELF-MFs) and reported the induction of functional changes in neuronal activity. In particular, ELF-MFs can influence synaptic plasticity both in-vitro and in animal models. Indeed, some studies reported an increase in long-term potentiation (LTP) whereas others suggested its reduction. However, no specific study has investigated such effect in humans. Aims: To evaluate whether ELF-MFs affect the propensity of the human cortex to undergo LTP-like plasticity. Methods: We designed a randomized, single-blind, sham-controlled, cross-over study on 10 healthy subjects. Cortical plasticity was induced by intermittent theta burst stimulation (iTBS) before and after 45-min ELF-MFs (75Hz;1.8mT) or sham exposure and was estimated by measuring the changes of motor evoked potentials (MEP) amplitude before and after each iTBS. Results: No adverse events were reported. No significant effects of ELF-MFs on cortical plasticity were found. Conclusion: Whole-brain exposure to ELF-MFs (75Hz;1.8mT) is safe and does not seem to significantly affect LTP-like plasticity in human motor cortex.

year	journal	country	edition	language
2020-02-01	Frontiers in human neuroscience

10.3389/fnhum.2020.00014 https://pubmed.ncbi.nlm.nih.gov/32116603