Changes in natriuretic peptide and cytokine plasma levels in patients with heart failure, after treatment with high dose of furosemide plus hypertonic saline solution (HSS) and after a saline loading

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RESEARCH PRODUCT

Changes in natriuretic peptide and cytokine plasma levels in patients with heart failure, after treatment with high dose of furosemide plus hypertonic saline solution (HSS) and after a saline loading

Giuseppe Licata Salvatore Corrao R. Di Sciacca Antonio Pinto Rosario Scaglione Antonino Tuttolomondo Domenico Di Raimondo Calogero Caruso

subject

Male medicine.medical_specialty Settore MED/09 - Medicina Interna medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Sodium Medicine (miscellaneous)chemistry.chemical_element Sodium Chloride Heart failure natriuretic petide cytokine furosemide Asymptomatic Gastroenterology Furosemide Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Saline Aged Aged 80 and over Heart Failure Saline Solution Hypertonic Nutrition and Dietetics business.industry Furosemide Middle Aged medicine.disease Hypertonic saline Cytokine Endocrinology chemistry Case-Control Studies Heart failure Cytokines Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug

description

BACKGROUND AND AIMS: Neurohormonal activation and inflammation characterizes heart failure, relates to outcome, and is a therapeutic target. The aim of this study was to evaluate the effects of high-dose furosemide plus small-volume hypertonic saline solutions (HSS) on natriuretic peptides and immuno-inflammatory marker levels and to analyze, after treatment, the response to acute saline loading. METHODS AND RESULTS: 120 patients with heart failure treated with high-dose furosemide+HSS (Furosemide/HSS group) were matched with: 30 subjects with heart failure treated with high-dose furosemide (furosemide group), 30 controls with asymptomatic left-ventricular dysfunction (ALVD) (asymptomatic group) and 30 controls without heart failure or ALVD (Healthy group). We evaluated plasma levels of natriuretic peptides and cytokine levels in baseline, after treatment and after acute saline load. After treatment with high-dose furosemide+HSS compared to treatment with furosemide alone we observed a significant lowering of ANP [96 (46.5-159.5)pg/ml vs 64 (21-150)pg/ml], BNP [215.5 (80.5-487)pg/ml vs 87 (66-141.5)pg/ml], TNF-alpha [389.5 (265-615.5)pg/ml vs 231.5 (156-373.5)pg/ml], IL-1beta [8 (7-9)pg/ml vs 4 (3-7)pg/ml], IL-6 [5 (3-7.5)pg/ml vs 3 (2-4)pg/ml], plasma values and after an acute saline load, a lower percentage change of ANP (+18.6% vs +28.03% vs +25% vs +29%), BNP (+14.5% vs +29.2% vs +30% vs +29.6%) TNF-alpha (+10.8% vs +15.8% vs +17.8% vs +11.3%), IL-1beta (+20% vs 34.4% vs 40% vs 34.4%) compared to control groups. CONCLUSIONS: Treatment with HSS could be responsible for a stretching relief that could influence natriuretic and immuno-inflammatory markers. Copyright © 2009 Elsevier B.V. All rights reserved.

year	journal	country	edition	language
2011-05-01	Nutrition, Metabolism and Cardiovascular Diseases

https://doi.org/10.1016/j.numecd.2009.10.014