Discovery of new G-quadruplex binding chemotypes

6533b859fe1ef96bd12b76c1

RESEARCH PRODUCT

Discovery of new G-quadruplex binding chemotypes

W. David Wilson Ingrida Pazitna Arvind Kumar Mekala Gunaratnam David W. Boykin Mohamed A. Ismail Ehsan Varavipour Rupesh Nanjunda Stephan A. Ohnmacht Stephen Neidle Gloria Di Vita

subject

Cell Survival Antineoplastic Agents 010402 general chemistry G-quadruplex 01 natural sciences Article Catalysis 03 medical and health sciences chemistry.chemical_compound Cell Line Tumor Furan Materials Chemistry Humans heterocyclic compounds Furans Cell survival 030304 developmental biology G quadruplex binding 0303 health sciences G-quadruplex Chemotype Chemistry Circular Dichroism Metals and Alloys General Chemistry Combinatorial chemistry In vitro 3. Good health 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials G-Quadruplexes Ceramics and Composites Selectivity

description

We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.

year	journal	country	edition	language
2013-12-05	Chem. Commun.

https://doi.org/10.1039/c3cc48616h

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