fitforthem
about

scope and guide to the platform

—research groups

research groups network graph visualization

—repositories

catalog of the institutional repositories

—heritage

selection of collections, museum, cultural sites and ancient books

By continuing your visit to this site, you accept the use of essential cookies.

Read more
6533b859fe1ef96bd12b76c1

RESEARCH PRODUCT

Discovery of new G-quadruplex binding chemotypes

W. David WilsonIngrida PazitnaArvind KumarMekala GunaratnamDavid W. BoykinMohamed A. IsmailEhsan VaravipourRupesh NanjundaStephan A. OhnmachtStephen NeidleGloria Di Vita

subject

Cell SurvivalAntineoplastic Agents010402 general chemistryG-quadruplex01 natural sciencesArticleCatalysis03 medical and health scienceschemistry.chemical_compoundCell Line TumorFuranMaterials ChemistryHumansheterocyclic compoundsFuransCell survival030304 developmental biologyG quadruplex binding0303 health sciencesG-quadruplexChemotypeChemistryCircular DichroismMetals and AlloysGeneral ChemistryCombinatorial chemistryIn vitro3. Good health0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsG-QuadruplexesCeramics and CompositesSelectivity

description

We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.

yearjournalcountryeditionlanguage
2013-12-05Chem. Commun.
https://doi.org/10.1039/c3cc48616h
EU flag

FORTHEM European University Alliance is co-funded by the European Union. FIT FORTHEM has received funding from the European Union's Horizon 2020 Research and Innovation Programme under grant agreement No. 101017248. The content of this website represents the views of the author only and is his/her sole responsibility; it cannot be considered to reflect the views of the European Commission.

University of Jyväskylä logoUniversity of Jyväskylä's websiteUniversity of Burgundy logoUniversity of Burgundy's websiteUniversity of Mainz logoUniversity of Mainz's websiteUniversity of Palermo logoUniversity of Palermo's websiteUniversity of Latvia logoUniversity of Latvia's website
University of Agder logoUniversity of Agder's websiteUniversity of Opole logoUniversity of Opole's websiteUniversity of Sibiu logoUniversity of Sibiu's websiteUniversity of València logoUniversity of València's website
FORTHEM logoFORTHEM alliance's website