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RESEARCH PRODUCT
Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments
Alexander AugustClaus U. PietrzikKlemens WildStefan Kinssubject
0301 basic medicineSynaptic cleftamyloid precursor protein (APP)Context (language use)ReviewNeurotransmission03 medical and health sciencesCellular and Molecular Neurosciencemental disordersAmyloid precursor proteinsynaptic transmissionAPLP1Molecular BiologybiologyChemistryzincP3 peptideCell biologyBiochemistry of Alzheimer's disease030104 developmental biologyAlpha secretaseBiochemistrycopperbiology.proteinAlzheimer’s diseaseNeurosciencedescription
Alzheimer’s disease (AD) is ultimately linked to the Amyloid Precursor Protein (APP). However, current research reveals an important synaptic function of APP and APP-like proteins (APLP1 and 2). In this context various neurotrophic and neuroprotective functions have been reported for the APP proteolytic fragments sAPPα, sAPPβ, and the monomeric amyloid-beta peptide (Aβ). APP is a metalloprotein and binds copper and zinc ions. Synaptic activity correlates with a release of these ions into the synaptic cleft and dysregulation of their homeostasis is linked to different neurodegenerative diseases. Metal binding to APP or its fragments affects its structure and its proteolytic cleavage and therefore its physiological function at the synapse. Here, we summarize the current data supporting this hypothesis and provide a model of how these different mechanisms might be intertwined with each other.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-31 | Frontiers in Molecular Neuroscience |